Molecular mechanisms by which T-bet regulates T-helper cell commitment
نویسندگان
چکیده
منابع مشابه
Lentivirally overexpressed T-bet regulates T-helper cell lineage commitment in chronic hepatitis B patients.
Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpression on Th cell differentiation and the possible mechanism in chronic hepatiti...
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We have previously shown that CD4(+) T cell-mediated allergic inflammation is diminished in signal transducer and activator of transcription (Stat)5a-deficient (Stat5a(-/-)) mice. To determine whether Stat5a regulates T helper cell differentiation, we studied T helper (Th)1 and Th2 cell differentiation of Stat5a(-/-)CD4(+) T cells at single-cell levels. First, Th2 cell differentiation from anti...
متن کاملt-helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
متن کاملT-cell differentiation: Commitment factors for T helper cells
The immune system is designed to eradicate a large variety of invading pathogens with minimum immunopathology. T helper cells, also known as CD4+ T cells, may be subdivided into the T helper 1 (Th1) and the T helper 2 (Th2) subsets, which produce distinct profiles of cytokines [1,2]. These Th1 and Th2 cells have opposing roles, regulating immune responses to intracellular and extracellular path...
متن کاملt helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2010
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2010.00952.x